Dorzolamide (trade name Trusopt) is a carbonic anhydrase inhibitor. It is an anti-glaucoma agent, and acts by decreasing the production of aqueous humour. It is administered as a topical ophthalmic in the form of a 2% solution.
The reference site for Dorzolamide
WHAT IS Dorzolamide?
Dorzolamide is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness.
This medication works by decreasing the amount of fluid within the eye. It belongs to a class of drugs known as carbonic anhydrase inhibitors.
Brand Name(s): Trusopt; Cosopt (combined withtimolol maleate)
CAS nº: 130693-82-2
(door ZOLE uh mide)
The sections below will provide you with more specific information and guidelines related to dorzolamide and its correct use. Please read them carefully.
Dorzolamide was approved by the US Food and Drug Administration in 1994. A prescription is required for this medicine.
Why is this medication prescribed?
Dorzolamide ophthalmic is used to treat open-angle glaucoma or high pressure in the eye. It belongs to a class of drugs known as carbonic anhydrase inhibitors. It works by reducing the amount of fluid in the eye, which in turn decreases pressure inside the eye.
Drug class and mechanism: many parts of the body, including the eye, contain the enzyme carbonic anhydrase. Carbonic anhydrase plays a key role in controlling the production of fluid particularly within the eye. In turn, the amount of fluid within in the eye determines the pressure within the eye (intraocular pressure). Dorzolamide blocks the enzyme, carbonic anhydrase, and is used as eye drops in the treatment of glaucoma, a condition in which the fluid and pressure in the eye is increased. Following administration of dorzolamide to the eye, intraocular pressure is lowered. This reduces the risk of nerve damage and loss of vision that is caused by increases of intraocular pressure in patients with glaucoma.
Other uses for this medicine
This medication has not been approved for any alternative uses other than those mentioned in the product information section.
Dosage and using this medicine
Read the Patient Information leaflet provided by your pharmacist before you start using dorzolamide and each time you get a refill. If you have any questions regarding the information, consult your doctor or pharmacist.
This medication is for use in the eye(s), usually one drop in the affected eye(s) 3 times a day, or as directed by your doctor.
To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.
The preservative in this product may be absorbed by contact lenses. If you wear contact lenses, remove them before using the eye drops. Wait at least 15 minutes after using this medication before putting in your contact lenses.
Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop in your eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Try not to blink and do not rub your eye. This will prevent the medication from draining out. Repeat these steps for your other eye if so directed.
Do not rinse the dropper. Replace the dropper cap after each use.
If you are using another kind of eye medication (e.g., drops or ointments), wait at least 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.
Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. It is important to continue using dorzolamide even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.
What special precautions should I follow?
BEFORE TAKING DORZOLAMIDE:
Please inform your doctor or pharmacist if you are allergic to this medication, sulfa drugs, the preservative in this product (benzalkonium chloride), or if you have any other allergies.
Tell your doctor or pharmacist your medical history, especially regarding kidney disease, kidney stones, or liver disease.
Moreover, let your doctor know if you are taking a carbonic anhydrase inhibitor by mouth. Oral carbonic anhydrase inhibitors include acetazolamide (Diamox®), dichlorphenamide (Daranide®), and methazolamide (Neptazane®).
Avoid using other eyedrops or eye medications except under the direction of your doctor. If you are using another eyedrop, wait at least 10 minutes between doses of dorzolamide ophthalmic and the other medication.
Drugs other than those listed here may also interact with dorzolamide ophthalmic. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of dorzolamide. You may be advised to start using a new bottle.
Use cautiously when engaging in activities requiring clear vision such as driving or using machinery because your vision may be temporarily blurred or unstable after applying this drug. So too, alcohol may worsen this effect so it is advised that you limit alcoholic beverages.
Additionally, this medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.
On the other hand, it is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.
What should I do if I forget a dose?
Apply the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and apply the next one as directed.
Do not use a double dose of this medication.
What side effects can this medication cause?
If you experience an allergic reaction (swelling of the lips, face, or tongue; difficulty breathing; closing of the throat; or hives) to dorzolamide ophthalmic, stop using the medication and seek emergency medical attention or contact your doctor immediately.
Less serious side effects may be more likely to occur. Continue to use dorzolamide ophthalmic and talk to your doctor if you experience:
burning, stinging, itching, or watering of the eye
sensitivity of the eye to sunlight
a change in taste
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
What storage conditions are needed for this medicine?
Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.
This product is normally colorless. Discard the solution if it changes color, becomes cloudy, or develops particles.
In case of an emergency/overdose
The symptoms of a dorzolamide ophthalmic overdose are unknown. If you suspect of an overdose, flush the eye with water and call an emergency room or poison control centre.
If the drops have been ingested (taken by mouth), call an emergency centre for advice.
PICTURES OF DORZOLAMIDE PRODUCTS
Below you will find images and specific information on the principal types of dorzolamide that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.
The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.
Strength(s): 10 ML
Imprint: COSOPT EYE DROPS
Manufacturer: MERCK & CO.
Manufacturer: MERCK & CO.